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緋栬泲鐧紸涓誨閲嶅搴忓垪(GARP)鏄綔浼忚漿鍖栫敓闀垮洜瀛?beta;1(LTGF-β1)鐨処鍨嬭法鑶滅粏鑳炶〃闈㈠鎺ュ彈浣擄紝鍦ㄦ椿鍖栫殑璋冭妭鎬緇嗚優(Tregs)鍜岃灝忔澘涓婂ぇ閲忚〃杈俱€侴APR鑳藉浠嬪杞寲鐢熼暱鍥犲瓙-β1(TGF-β1)鐨勯噴鏀撅紝鍦ㄨ偪鐦ゅ唴閮紝TGF-βs錛屽挨鍏舵槸TGF-β1錛屼細鍒烘縺鍩鴻川緇嗚優澧炵敓銆佹柊琛€綆″艦鎴愩€佺檶緇嗚優杞Щ鍙婃姂鍒跺厤鐤粏鑳炴蹈娑︺€傛柊鐮旂┒鍙戠幇錛孴GF-β鏄厤鐤鏌ョ偣鎶戝埗鍓傚湪鑲跨槫寰幆澧冧腑鑰愯嵂鐨勪富瑕佸師鍥犮€傚熀浜庢錛孏ARP/TGF-β1鏄疶reg緇嗚優鍏鋒湁鍏嶇柅鎶戝埗鍔熻兘鐨勬牳蹇冩満鐞嗕箣涓€銆傛姂鍒惰偪鐦ゅ井鐜Treg緇嗚優琛ㄩ潰GARP閲婃斁TGF-β1鍔熻兘錛屾槸姝ら澏鐐逛富瑕佺殑鎴愯嵂鏈哄埗, 涔熸槸綺懼噯鍏嶇柅鑲跨槫娌葷枟瀵勪笌鍘氭湜鐨勬綔鍔涢澏鐐廣€?/p>
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鈶燤etelli, Alessandra et al. “Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer.” Journal of hematology & oncology. 2018, 11(1): 24
鈶atoh, Kazuki et al. “Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells.” International immunology. 2021, 33(8): 435-446.
鈶uende, Julia, et al. "Monoclonal antibodies against GARP/TGF-β1 complexes inhibit the immunosuppressive activity of human regulatory T cells in vivo." Science translational medicine. 2015, 7(284): 284ra56.
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緗戝弸璇勮